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Glimepiride is completely metabolized by oxidative biotransformation after either an IV or oral dose. The major metabolites are the cyclohexyl hydroxy methyl derivative (M1) and the carboxyl derivative (M2). CYP2C9 is involved in the biotransformation of glimepiride to M1. M1 is further metabolized to M2 by one or several cytosolic enzymes. In animals.M1 possesses about one-third of the pharmacological activity of glimepiride.but it is unclear whether M1 results in clinically meaningful effects on blood glucose in humans. M2 is inactive.

Know the medicines you take. Keep a list of your medicines and show it to your doctor and pharmacist before you start a new medicine. They will tell you if it is okay to take DUETACT with other medicines.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

This medication can cause low blood sugar (hypoglycemia). This may occur if you do not consume enough calories from food or if you do unusually heavy exercise. Symptoms include cold sweat.blurred vision.dizziness.drowsiness.shaking.fast cheap duetact.headache.fainting.tingling of the hands/cheap duetact.and hunger. It is cheap duetact good habit to carry glucose tablets or gel to treat low blood sugar. If you don’t have these reliable forms of glucose.cheap duetact raise your blood sugar by eating a quick source of sugar such as table sugar.honey.or candy.or drink fruit juice or non-diet soda. Tell your doctor about the reaction right away. To help prevent low blood sugar.eat meals on a regular schedule.and do not skip meals. Check with your doctor or pharmacist to find out what you should do if you miss a meal.

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consequently, duetact should not be used in patients with active bladder cancer and the benefits of glycemic control versus unknown risks for cancer recurrence with duetact should be considered in patients with a prior history of bladder cancer.


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